TEAM GregChrisChasKaren



     STI  2006 provided considerable background in epidemiology and modeling.  Our


team decided to build on this information and to select a disease currently afflicting


 human populations . Rather than focus on those diseases induced by a particular


 etiologic agent (avian flu, aids, smallpox, plague, dengue fever, malaria, tuberculosis,


 Hanta, tularemia, SARS, Legionaires, cholera, typhoid, sleeping sickness, Chaga’s


disease, brucellosis, anthrax, elephantiasis, condylamata lata, mad cow disease,


Lyme,West Nile, swine flu, etc.) we wanted to direct our project toward disease inherited


 and passed on to future generations. Initially, we considered genetically endorsed


diseases such as Alzheimer’s, Aspberger’s Syndrome, Diabetes type I, Gaucher’s


Disease, Haemophilia,Jakob-Cruzfeldt Syndrome, Lou Gehrig ‘s Disease, Muscular


 Dystrophy, Marfan Syndrome, Sickle Cell Anaemia, Tay-Sachs Disease, etc.


      Currently , in the USA, all newborns are screened via programs  in 46 of 50 states for


 sickle cell trait.  We felt that this database would provide us with better information to


 model Sickle Cell Anaemia rather than any of the other prominent and/or prevalent


 genetically induced diseases.  This disease is predominantly found in people of


Mediterranean, Indian, and African descent but not exclusive to them.  We looked into


 the nature of the disease which is caused by a single gene mutation that codes for the


 hemoglobin protein.  A person can be homozygous recessive (diseased), heterozygous,


 or homozygous dominant (non-carrier, unafflicted).   Recent studies reveal that the


 heterozygous state has an 8 to 10% prevalence in the USA with 0.5%  of those diseased.


      The prevalence rate allowed us to begin to think about the program with this as the


starting point. Marez and Alme initially wanted to create an array using JAVA but with


Mentor  Brian Lewis (adjunct professor of Math, Kent State Univ) changed to a vector


oriented approach .  The model includes an initial population of equal numbers of males


and females.








Sources for some of this aforementioned stuff:


“Mortality among children with sickle cell disease identified by newborn screening during 1990-1994” March 13,1998, Morbidity and Mortality Weekly Report

July 24,2006


“Mortality in sickle cell disease; Life expectancy and risk factors for early death”  July 24, 2006


“Sickle Cell Anaemia” 2006, by Ashok Raj,MD, July21,2006


“Sickle Cell Anemia; Hemoglobin SS disease (Hb SS)”   July 24, 2006

Reviewed by: A.D.A.M editorial. Previously reviewed by Jacqueline A. Hart, M.D., Department of Internal Medicine, Newton-Wellesley hospital, Harvard University.


“Sickle cell anaemia and S-thalassemia in Sicilian children”, 1992,  by Giovanna Russo and Gino Schiliro.   July 21,2006



“United States Birth Rate Information” CIA World Fact Book, January 1, 2005,   July 24, 2006